Solutions

Controlled Flow Infusion (CoFI) for MVO

Current Treatment?

How it works?

Action clip showing the importance of treating the microvascular system – show visual breaking up and restoring flow.

CorFlow has developed the Controlled Flow Infusion (CoFI) System for MVO: Early diagnosis and targeted delivery of treatment in the cath lab, within minutes.

Diagnosis of MVO in the Cathlab

In-stent occlusion and controlled infusion combined with measurement of back-pressure response in less than 2 minutes.

Early assessment of microvascular status.

Targeted Delivery of Therapeutic Agents

Address stent occlusion with intracoronary infusion of therapeutic agents in less than 10 minutes.

Delayed wash-out, increased dwelling time, “massage” of drug into obstructed vessels.

To validate

CorFlow CoFI console Gen 2

  • MVO diagnosis directly in the cathlab within minutes – a market first
  • Targeted delivery of therapeutic agents directly after MVO diagnosis – a market first
  • Fully integrated system – learnings implemented from Gen 1 and FIH clinical study
  • Ability to upgrade software as a platform with AI capability
  • CoFI infusion cassette for fast setup and sterile, single-use design

CorFlow CoFI catheter Gen 2

  • Proprietary occlusion-infusion catheter
  • 6 French guide catheter compatibility for radial or femoral approach
  • Compatible with stent sizes 2.75 – 5mm

Benefit For Physical Mental
and Virtual Care

Microcirculatory / microvascular dysfunction remains an area of massive unmet need in >20M people annually – it accounts for 1/6 below-the-knee amputations, 1/4 ischemic stroke patients, and 1/2 of all INOCA patients (70% female)

Reperfusion injury occurs in multiple organs as “collateral damage” when restoring blood flow

The global reperfusion market today is highly fragmented, $1.4B with a 5% CAGR and ripe for disruption

CorFlow represents a new approach, including next generation AI utilization for both diagnostics and therapy delivery with drug/device combinations not previously feasible