Our Technology

CorFlow has developed the Controlled Flow Infusion (CoFI) System for MVO: Early diagnosis and targeted delivery of treatment in the cath lab, immediately following primary PCI.

Diagnosis of MVO in the Cathlab

In-stent occlusion and controlled infusion combined with measurement of pressure response to provide an early assessment of microvascular function.

Diagnosis of MVO in the Cathlab

In-stent occlusion and controlled infusion combined with measurement of pressure response to provide an early assessment of microvascular function.

Targeted Delivery of Therapeutic Agents

In-stent occlusion with intracoronary infusion of therapeutic agents. The CoFI system is designed to delay wash-out, increase dwelling time, and “massage” of drug into obstructed vessels.

Targeted Delivery of Therapeutic Agents

In-stent occlusion with intracoronary infusion of therapeutic agents. The CoFI system is designed to delay wash-out, increase dwelling time, and “massage” of drug into obstructed vessels.

CorFlow CoFI system

The CoFI System is designed for diagnostic assessment of the coronary microcirculation immediately following percutaneous coronary intervention (PCI), and to act as a platform for controlled infusion of physician-specified diagnostic and therapeutic agents into the microcirculation.

CorFlow’s platform consists of a pressure sensing guidewire, the CoFI Catheter and the CoFI Console with the CoFI Cassette forming an infusion pump and proprietary algorithm that measures, in real-time, the heart’s pressure response to controlled flow infusions and computes diagnostic parameters that are indicative for MVO presence, that clinicians were not previously able to measure in the cath lab.

The CoFI System is indicated for diagnostic assessment of the coronary microcirculation immediately following percutaneous coronary intervention (PCI), and to act as a platform for controlled infusion of physician-specified diagnostic and therapeutic agents into the microcirculation.

The CoFI System uses a proprietary algorithm to diagnose microvascular obstruction (MVO) by measuring real-time distal coronary back-pressure response to a dynamic infusion sequence and can be used for targeted intracoronary infusion of physician-specified therapeutic agents. In addition to the primary target of ACS STEMI and NSTEMI applications, the technology has capabilities to address other indications in both coronary and broader vascular use cases. 

CoFI Console
  • Capital equipment that acts as an infusion pump together with the CoFI Cassette;
  • Automatic delivery of infusates (diagnostic and therapeutic) at controlled flow rates;
  • Calculate and display of physiological parameters to support detection of MVO;
  • GUI screen to guide user through console preparation and procedure steps;
  • Display of invasive blood pressures, intracoronary distal pressure, balloon inflation pressure, flow rates of the pump, infusion and occlusion times, and delivered fluid volumes.
CoFI Catheter
  • Infusion-occlusion balloon catheter;
  • 6 French guide catheter compatibilty to fit the STEMI workflow;
  • Compatible to 0.014” pressure wire;
  • 3-lumen catheter shaft design for axial infusion during vessel occlusion.
CoFI Cassette
  • Single-use sterile cassette to be introduced in CoFI console to act as infusion pump;
  • Allows easy and fast system preparation.
Watch our CEO, Paul Mead, present on the unmet clinical need and the CorFlow solution.